The identification of ‘boosters’ that drive gene overexpression directly in a CAR construct provides a simple and scalable strategy for developing effective CAR-NK cell therapies for solid tumours.
To our knowledge, these two exceptions have not been a barrier to accelerating the adoption and use of our models within our armed forces to date.
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Storage Nightmare: A CH car profile for a region can be massive (e.g., OSRM's Europe is tens of GBs, their global car profile around 200GB for just one profile). Our goal was to keep all profiles and parameters for the entire planet well under 20GB.
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