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ACH病因明确，由FGFR3基因的功能获得性突变导致。该基因调控骨骺生长板软骨细胞增殖分化的重要负调节因子，当其持续激活时，长骨生长被抑制，最终形成特征性的四肢短小身材。
，这一点在爱思助手下载最新版本中也有详细论述
ChandelureIntroduced in Gen V (2010)
"Although I am not an expert, this suggests that there needs to be some steps taken to make this area safe," Walker said.